A Rapid Synthetic Molecular Evolution Platform for Novel Antimicrobials Against Infections

Functional quinoline-malononitriles for enhanced wound repair and monitoring

R Moses, S Ding, T Zhang, AJ Sloan, Y Hong, W Li

2026-05-05

Wound healing is a complex biological process that, when disrupted, can result in chronic wounds and substantial healthcare burden..

A Dual-Model Machine Learning Framework for Interpretable Design and Ensemble Prediction of C-Amidated Antimicrobial Peptides

DH Le, Y Zhu, T Zhang, W Li, A Hung, S Houshyar, TC Le

2026-03-18

Antimicrobial peptides (AMPs) offer promising alternatives to conventional antibiotics, yet most predictive models fail to account..

Aggregation-prone antimicrobial peptides target gram-negative bacterial nucleic acids and protein synthesis

P Chen, T Zhang, C Li, P Praveen, K Parisi, C Beh, S Ding, JD Wade, Y Hong, S Li, JN Nkoh, A Hung, W Li, C Shang

2025-01-15

Aggregation of antimicrobial peptides (AMPs) enhances their efficacy by destabilising the bacterial cell wall, membrane, and cytos..

Recent Toolboxes for Chemoselective Dual Modifications of Proteins

Y Zhao, T Zhang, Y Zhu, J Yin, R Omer, X Hemu, W Li, X Bi

2024-10-08

Site-selective chemical modifications of proteins have emerged as a potent technology in chemical biology, materials science, and ..

Embracing the era of antimicrobial peptides with marine organisms

P Chen, T Ye, C Li, P Praveen, Z Hu, W Li, C Shang

2024-01-01

Covering: 2018 to Jun of 2023 The efficiency of traditional antibiotics has been undermined by the proliferation of antibiotic-res..

The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency: Special Issue: Emerging Investigators

B Lin, A Hung, W Singleton, KK Darmawan, R Moses, B Yao, H Wu, A Barlow, MA Sani, AJ Sloan, MA Hossain, JD Wade, Y Hong, NM O'Brien-Simpson, W Li

2023-08-01

Antimicrobial peptides (AMPs) are potentially powerful alternatives to conventional antibiotics in combating multidrug resistance,..

Chemical and Biological Strategies for Profiling Protein-Protein Interactions in Living Cells

YY Wang, W Li, BC Ye, XB Bi

2023-07-17

Protein-protein interactions (PPIs) play critical roles in almost all cellular signal transduction events. Characterization of PPI..

The overview of antimicrobial peptide-coated implants against oral bacterial infections

Z Sun, L Ma, X Sun, AJ Sloan, NM O'Brien-Simpson, W Li

2023-06-01

Dental implants are the most common therapeutic approach for resolving tooth loss and damage. Despite technical advances in treatm..

Directed chemical dimerisation enhances the antibacterial activity of the antimicrobial peptide MSI-78(4–20)

Rong Li, Thomas NG Handley, Wenyi Li, Neil M O’Brien-Simpson, Mohammed Akhter Hossain, John D Wade

2023-05-31

Antimicrobial resistance (AMR) is on the rise, leading to 700 000 deaths worldwide in 2020. Antimicrobial peptides (AMPs) are ant..